Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state.

Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state.

A surprising portion of both mammalian and Drosophila genomes are transcriptionally paused, undergoing initiation without elongation. We tested the hypothesis that transcriptional pausing is an obligate transition state between definitive activation and silencing as human embryonic stem cells (hESCs...

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Bibliographic Details
Main Authors: Jonathan L Golob, Roshan M Kumar, Matthew G Guenther, Lil M Pabon, Gabriel A Pratt, Jeanne F Loring, Louise C Laurent, Richard A Young, Charles E Murry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0022416&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0022416&type=printable

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