CRISPR/Cas9-engineering of Kell null erythrocytes to unveil host targeted irresistible antimalarial

CRISPR/Cas9-engineering of Kell null erythrocytes to unveil host targeted irresistible antimalarial

Abstract Malaria elimination faces challenges from drug resistance, stemming from mutations within the parasite’s genetic makeup. Genetic adaptations in key erythrocyte proteins offer malaria protection in endemic regions. Emulating nature’s approach, and implementing methodologies to render indispe...

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Main Authors: Geeta Kumari, Pragya Gupta, Sangam G. Goswami, Ravi Jain, Sakshi Anand, Shreeja Biswas, Swati Garg, Priya Thakur, Vinodh Saravanakumar, V. R. Arvinden, Bidhan Goswami, Ipsita Pal Bhowmick, Narla Mohandas, Jeremy Burrows, Sivaprakash Ramalingam, Shailja Singh
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07968-2
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https://doi.org/10.1038/s42003-025-07968-2

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