Orthotopic meningioma rat model exhibits morphological and immunohistochemical congruency and epigenetic concordance with benign primary patient-derived tumors

Orthotopic meningioma rat model exhibits morphological and immunohistochemical congruency and epigenetic concordance with benign primary patient-derived tumors

Abstract Meningiomas are the most common primary central nervous system tumor. Clinical trials have failed to support effective medical treatments, despite initially promising animal studies. A key issue could be that available experimental models fail to mimic the clinical situation. Hence, there i...

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Main Authors: Mikkel Schou Andersen, Bo Halle, Martin Wirenfeldt, Jeanette Krogh Petersen, Morten Winkler Møller, Philipp Jurmeister, Birgitte Brinkmann Olsen, Bjarne Winther Kristensen, Henning Boldt, Christian Bonde Pedersen, Tiit Mathiesen, Frantz Rom Poulsen
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Meningioma
Xenograft
Orthotopic tumor model
In vivo
DNA methylation profiling
Online Access:https://doi.org/10.1038/s41598-024-83456-7
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https://doi.org/10.1038/s41598-024-83456-7

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