Regenerating aged bone marrow via a nitric oxide nanopump

Abstract Resident leptin-receptor-expressing (LepR+) cells senescence in the aged bone marrow impairs the regenerative capacity of osteo- and other lineages of cells. In this study, a LepR+ cell-targeting nitric oxide (NO) nanopump with in vivo self-controlled turn-on ability was constructed to reju...

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Bibliographic Details
Main Authors: Ke Li, Sihan Hu, Hanwen Li, Wenzheng Lin, Duoyi Zhao, Zhuobin Xu, Chun Pan, Huihui Wang, Dandan Li, Jingjing Liu, Hao Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61256-5
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