Development of a cuproptosis-related prognostic signature to reveal heterogeneity of the immune microenvironment and drug sensitivity in acute lymphoblastic leukemia

Development of a cuproptosis-related prognostic signature to reveal heterogeneity of the immune microenvironment and drug sensitivity in acute lymphoblastic leukemia

Abstract Background Cuproptosis is a brand-new copper-dependent type of cell death that has been linked to various tumors. However, the relationship between cuproptosis and acute lymphoblastic leukemia (ALL) remains to be further elaborated. Methods In ALL, 12 cuproptosis-related genes (CRGs) were a...

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Main Authors: Bingxin Zhang, Shuxia Zhu, Dong Zheng, Xinyi Zhang, Wenxia Xie, Shujuan Zhou, Sisi Zheng, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Zixing Chen, Enqing Lan, Luning Cui, Hansen Ying, Yu Zhang, Xuanru Lin, Qiang Zhuang, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma
Format: Article
Language:English
Published: BMC 2025-05-01
Series:European Journal of Medical Research
Subjects:
Acute lymphoblastic leukemia
Cuproptosis
Prognostic gene signature
Tricarboxylic acid (TCA) cycle
Tumor microenvironment (TME)
Immunotherapy
Online Access:https://doi.org/10.1186/s40001-025-02572-w
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https://doi.org/10.1186/s40001-025-02572-w

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