Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease

Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease

IntroductionInflammatory bowel disease (IBD), a chronic immune-mediated gastrointestinal disorder mainly covering Crohn's Disease and Ulcerative Colitis, has an unclear etiology. The exploration of novel intervention strategies remains a key scientific issue that is urgently needed for IBD trea...

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Main Authors: Caiyi Yuan, Qiang Wang, Yuying Chen, Xin Ding, Qiang Zhang, Jiakai Yao, Bei Zhang, Yang Dai, Hongxia Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
Nippostrongylus brasiliensis
uridine
apical sodium-dependent bile acid transporter
inflammatory bowel disease
RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1600838/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1600838/full

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