Selective toxicity of a novel antimicrobial peptide Acidocin 4356 against Pseudomonas aeruginosa and Acinetobacter baumannii in human cell-based in vitro infection models

Selective toxicity of a novel antimicrobial peptide Acidocin 4356 against Pseudomonas aeruginosa and Acinetobacter baumannii in human cell-based in vitro infection models

Abstract Prior studies examined Acidocin 4356’s antibacterial and antivirulence effects against Pseudomonas aeruginosa, including cell membrane penetration abilities. Building on prior research, an in-vitro co-culture of human cells was established to evaluate the selectivity of Acidocin (ACD) by co...

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Bibliographic Details
Main Authors: Mahbubeh Talaee, Sima Modiri, Marzieh Rajabi, Fatemeh Saadati, Ali Akbari, Sahar Javadi, Shuaiqi Guo, Hojatollah Vali, Kambiz Akbari Noghabi
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Acidocin 4356
Multidrug-resistant pathogens
Pseudomonas aeruginosa
Acinetobacter baumannii
Cytotoxicity
Cell selectivity
Online Access:https://doi.org/10.1038/s41598-025-86115-7
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https://doi.org/10.1038/s41598-025-86115-7

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