Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity.

Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity.

During adulthood, the neurotrophin Nerve Growth Factor (NGF) sensitizes nociceptors, thereby increasing the response to noxious stimuli. The relationship between NGF and pain is supported by genetic evidence: mutations in the NGF TrkA receptor in patients affected by an hereditary rare disease (Here...

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Bibliographic Details
Main Authors: Simona Capsoni, Sonia Covaceuszach, Sara Marinelli, Marcello Ceci, Antonietta Bernardo, Luisa Minghetti, Gabriele Ugolini, Flaminia Pavone, Antonino Cattaneo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017321&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017321&type=printable

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