Clinical and in vitro models identify distinct adaptations enhancing Staphylococcus aureus pathogenesis in human macrophages.

Clinical and in vitro models identify distinct adaptations enhancing Staphylococcus aureus pathogenesis in human macrophages.

Staphylococcus aureus is a facultative intracellular pathogen of human macrophages, which facilitates chronic infection. The genotypes, pathways, and mutations influencing that phenotype remain incompletely explored. Here, we used two distinct strategies to ascertain S. aureus gene mutations affecti...

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Main Authors: Dustin R Long, Elizabeth A Holmes, Hsin-Yu Lo, Kelsi Penewit, Jared Almazan, Taylor Hodgson, Nova F Berger, Zoe H Bishop, Janessa D Lewis, Adam Waalkes, Daniel J Wolter, Stephen J Salipante
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012394
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https://doi.org/10.1371/journal.ppat.1012394

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