Flecainide mediated sodium channel blockade enhances blood brain barrier integrity and promotes neuroprotection in neuroinflammation

Flecainide mediated sodium channel blockade enhances blood brain barrier integrity and promotes neuroprotection in neuroinflammation

Abstract Multiple Sclerosis (MS), an autoimmune disorder, is characterized by severe neuroinflammation, leading to demyelination and neuronal damage in the CNS, resulting in significant clinical impairment. MS progression involves complex pathological processes like immune cell invasion and cytokine...

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Main Authors: Mustafa Sindi, Diana Klees, Vera Dobelmann, Paul Disse, Hanne Weigel, Stefanie Lichtenberg, Rebekka Ricci, Leonie Thewes, Gülsüm Deniz-Köseoglu, Christina Hecker, Thomas Müntefering, Andrea Issberner, Joel Gruchot, Hans-Peter Hartung, Tobias Ruck, Carsten Berndt, Thomas Kurz, Holger Stark, Patrick Küry, Britta Engelhardt, Ruth Lyck, Sven G. Meuth, Michael Dietrich, Philipp Albrecht
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Flecainide
Rasagiline
Safinamide
Sodium-channel blocking
MAO-B inhibition
Neuroprotection
Online Access:https://doi.org/10.1038/s41598-025-15430-w
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https://doi.org/10.1038/s41598-025-15430-w

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