Mitigation of P. gingivalis-exacerbated intestinal inflammation by paeoniflorin through alteration of the gut microbiota

Mitigation of P. gingivalis-exacerbated intestinal inflammation by paeoniflorin through alteration of the gut microbiota

ABSTRACT Porphyromonas gingivalis is a well-known periodontal pathogen that has also been linked to systemic diseases. In this study, our results revealed that P. gingivalis exacerbated inflammation, as indicated by weight loss, decreased colon length, and increased colonic tissue inflammation. Furt...

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Main Authors: Ru Qu, Ming Li, Ping Li, Ying Song, Biao Dong, Juan Liu, Xuan Mo, Zhenjiang Zech Xu, Xiaochang Huang
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
paeoniflorin
Porphyromonas gingivalis
gut microbiota
metabolomic
intestinal inflammation
gut metabolism
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00002-24
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https://journals.asm.org/doi/10.1128/spectrum.00002-24

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