Small extracellular vesicles from human bone marrow mesenchymal stromal cells enhance migration and regulate reparative gene expression in dermal fibroblasts

Small extracellular vesicles from human bone marrow mesenchymal stromal cells enhance migration and regulate reparative gene expression in dermal fibroblasts

Abstract Studies have shown that mesenchymal stromal cells (MSCs) could secrete a variety of bioactive particles, including small extracellular vesicles (sEVs), that might be a key intermediate to the beneficial paracrine effects of MSC therapy. In this study, we harvested the conditioned medium (CM...

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Bibliographic Details
Main Authors: Rui Lei, Tamiris Borges da Silva, Zhanfeng Cui, Hua Ye
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Extracellular vesicles
Mesenchymal stromal cells
RNA sequencing
Fibroblasts
Migration
Online Access:https://doi.org/10.1038/s41598-025-04057-6
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https://doi.org/10.1038/s41598-025-04057-6

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