Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease.

Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease.

<h4>Background</h4>There is an urgent need for improved treatments for Chagas disease, a neglected tropical infection caused by the protozoan parasite Trypanosoma cruzi. Benznidazole, the first line therapy, has severe limitations such as poor tolerability and variable efficacy in the ch...

Full description

Saved in:
Bibliographic Details
Main Authors: Frauke Assmus, Ayorinde Adehin, Richard M Hoglund, Amanda Fortes Francisco, Michael D Lewis, John M Kelly, Susan A Charman, Karen L White, David M Shackleford, Fanny Escudié, Eric Chatelain, Ivan Scandale, Joel Tarning
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0012968
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1371/journal.pntd.0012968

Similar Items