Transcriptome analysis of atad3-null zebrafish embryos elucidates possible disease mechanisms

Transcriptome analysis of atad3-null zebrafish embryos elucidates possible disease mechanisms

Abstract Background ATAD3A, a nuclear gene encoding the ATAD3A protein, has diverse roles in mitochondrial processes, encompassing mitochondrial dynamics, mitochondrial DNA maintenance, metabolic pathways and inter-organellar interactions. Pathogenic variants in this gene cause neurological diseases...

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Main Authors: Shlomit Ezer, Nathan Ronin, Shira Yanovsky-Dagan, Shahar Rotem-Bamberger, Orli Halstuk, Yair Wexler, Zohar Ben-Moshe, Inbar Plaschkes, Hadar Benyamini, Ann Saada, Adi Inbal, Tamar Harel
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Orphanet Journal of Rare Diseases
Subjects:
ATAD3A
CRISPR/Cas9
Zebrafish knockout model
Transcriptome
RNA-seq
Mitochondria
Online Access:https://doi.org/10.1186/s13023-025-03709-0
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https://doi.org/10.1186/s13023-025-03709-0

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