TRPC6-Calpain-1 Axis Promotes Tubulointerstitial Inflammation by Inhibiting Mitophagy in Diabetic Kidney Disease

TRPC6-Calpain-1 Axis Promotes Tubulointerstitial Inflammation by Inhibiting Mitophagy in Diabetic Kidney Disease

Introduction: Renal tubulointerstitial inflammation represents an effective indicator for predicting the progression of diabetic kidney disease (DKD). Mitophagy abnormality is 1 of the most important factors involved in tubule injury. However, the exact molecular mechanism underlying mitophagy abnor...

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Main Authors: Cong-Cong Liu, Jia-Ling Ji, Ze Wang, Xing-Jian Zhang, Lin Ding, Yao Zhang, Yan Zhou, Dong-Jie Zhang, Zhen-Lin Tang, Jing-Yuan Cao, Ai-Qing Zhang, Bi-Cheng Liu, Zuo-Lin Li, Rui-Xia Ma
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Kidney International Reports
Subjects:
calpain-1
diabetic kidney disease
mitophagy
TRPC6
tubulointerstitial inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024924019041
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