UMI-77 targets MCL-1 to activate mitophagy and ameliorate periodontitis in mice

UMI-77 targets MCL-1 to activate mitophagy and ameliorate periodontitis in mice

Objective: To investigate the therapeutic and ameliorative effects of the Myeloid Cell Leukemia 1 protein (MCL-1) inhibitor UMI-77 on experimental murine periodontitis via mitophagy activation, with a focus on comparing administration routes (local/intraperitoneal) and doses (high/low/combined). Met...

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Bibliographic Details
Main Authors: Dalei Sun, Shu Ouyang, Xiaoxuan Xu, Jingjing Yan, Heqian Wang, Chenkai Lan, Wubin Ouyang, Liangjun Zhong, Jun Lin
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Immunobiology
Subjects:
Periodontitis
UMI-77
MCL-1
Mitophagy
Targeted therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0171298525002426
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http://www.sciencedirect.com/science/article/pii/S0171298525002426

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