The unexplored mechanism of antitumoral effect of pirfenidone in melanoma cells

The unexplored mechanism of antitumoral effect of pirfenidone in melanoma cells

Abstract Melanoma is still one of the most aggressive cancers, with global incidence and mortality rates expected to rise significantly by 2040. Surgical excision with adequate safety margins remains the standard treatment for primary cutaneous melanoma. However, the therapeutic approach to treat ad...

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Bibliographic Details
Main Authors: Melissa Marchese, Gilda La Regina, Rachele Amato, Gianmarco Bertoni, Jessica Ruzzolini, Daniele Martinucci, Laura Papucci, Silvia Peppicelli, Francesca Bianchini
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Melanoma
Pirfenidone
Transforming Growth Factorβ TGFβ
Drug repurposing
Online Access:https://doi.org/10.1038/s41598-025-13584-1
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https://doi.org/10.1038/s41598-025-13584-1

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