Beta sitosterol inhibits the proliferation and migration of synoviocytes in rheumatoid arthritis via lactylation of GPI

Beta sitosterol inhibits the proliferation and migration of synoviocytes in rheumatoid arthritis via lactylation of GPI

Abstract Fibroblast-like synoviocytes (FLSs) are critical for promoting joint and surrounding soft tissue damage in Rheumatoid arthritis (RA). β-Sitosterol has the potential to attenuate RA; however, the underlying mechanism remains largely unknown. This study aimed to investigate the effect of β-Si...

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Bibliographic Details
Main Authors: Yongzhen Tan, Xunlong Zhong, Xiangping He, Yuying Yuan, Yunfeng Deng, Jingjie Huang, Yao Zhou, Chuhai Xie, Huaidong Peng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Rheumatoid arthritis
β-Sitosterol
Lactylation
GPI
LDHA
Online Access:https://doi.org/10.1038/s41598-025-10928-9
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https://doi.org/10.1038/s41598-025-10928-9

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