TP63 as a modulator of ferroptosis in TP53 mutations glioblastoma

Abstract Glioblastoma (GBM) is a highly aggressive brain tumor with limited effective treatment options. Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, has emerged as a potential vulnerability in GBM, yet its regulatory mechanisms remain poorly defined. In t...

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Bibliographic Details
Main Authors: Haiping Cai, Jiahao Yang, Feifei Luo, Wu Gan, Yanwen Li, Liang Zhang, Xueying Ke, Alafate Wahafu, Danian Dai, Peng Wang, Dong Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07938-w
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