Plumbagin Triggers Cuproptosis in Hepatocellular Carcinoma (HCC) via the DNA‐Methyltransferase 1 (DNMT1)/microRNA‐302a‐3p (miR‐302a‐3p)/ATPase Copper Transporting Beta (ATP7B) Axis

Plumbagin Triggers Cuproptosis in Hepatocellular Carcinoma (HCC) via the DNA‐Methyltransferase 1 (DNMT1)/microRNA‐302a‐3p (miR‐302a‐3p)/ATPase Copper Transporting Beta (ATP7B) Axis

ABSTRACT Induction of cuproptosis in tumor cells is an emerging direction for cancer drug development. Plumbagin (PLB), a natural biological molecule, has anticancer activities, partially via copper‐dependent mechanisms. But it remains unclear if PLB can induce cuproptosis in hepatocellular carcinom...

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Bibliographic Details
Main Authors: Chuyu Wang, Hao Wang, Chong Wang, Tongtong Tian, Anli Jin, Yu Liu, Ran Huo, Te Liu, Baishen Pan, Wei Guo, Wenjing Yang, Beili Wang
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:MedComm
Subjects:
ATPase copper transporting beta (ATP7B)
cuproptosis
DNA‐methyltransferase 1 (DNMT1)
hepatocellular carcinoma (HCC)
plumbagin (PLB)
Online Access:https://doi.org/10.1002/mco2.70312
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https://doi.org/10.1002/mco2.70312

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