Development of iPSC-derived T cells targeting EGFR neoantigens in non-small cell lung cancer

Development of iPSC-derived T cells targeting EGFR neoantigens in non-small cell lung cancer

A long-sought goal of cancer immunotherapy is to mass-produce T cells that specifically target tumor neoantigens. One decisive challenge is the identification of neoantigens derived from cancer driver genes. Here, we identify T cells that recognize the NSCLC-associated EGFR C797S mutation, which con...

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Bibliographic Details
Main Authors: Kouta Niizuma, Toshinobu Nishimura, Jonathan Villanueva, Laura Amaya, Jonas L. Fowler, Taichi Isobe, Yusuke Nakauchi, Brandon Saavedra, Haojun Xu, Mahito Nakanishi, Adam C. Wilkinson, Kyle M. Loh, Joseph B. Shrager, Hiromitsu Nakauchi
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
T cell
iPS cells
rejuvenation
cancer antigen
neoepitope
TCR
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125001123
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