FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system

Abstract Myelin, along with the oligodendrocytes (OLs) that produce it, is essential for proper central nervous system (CNS) function in vertebrates. Although the accurate targeting of myelin to axons and its maintenance are critical for CNS performance, the molecular pathways that regulate these pr...

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Bibliographic Details
Main Authors: Hannah Y. Collins, Ryan A. Doan, Jiaxing Li, Jason E. Early, Megan E. Madden, Tyrell Simkins, David A. Lyons, Kelly R. Monk, Ben Emery
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62715-9
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