Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation

Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation

The selective regulation of gene expression at the RNA level represents a rapidly evolving field offering substantial clinical potential. This review examines the molecular mechanisms of intracellular enzymatic systems that utilize single-stranded nucleic acids to downregulate specific RNA targets....

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Bibliographic Details
Main Authors: Daria A. Chiglintseva, Olga A. Patutina, Marina A. Zenkova
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomolecules
Subjects:
RNA-targeted therapy
RNase H1
RNase P
AGO2
antisense oligonucleotide
EGS
Online Access:https://www.mdpi.com/2218-273X/15/7/965
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