Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non‐Amplification of Activin A‐ACVR2B‐NOX4 Axis Pathway

Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non‐Amplification of Activin A‐ACVR2B‐NOX4 Axis Pathway

Abstract Although activin receptor IIB (ACVR2B) is emerging as a novel pathogenic receptor, its ligand and assembled components (or assembly) are totally unknown in the context of osteoarthritis (OA) pathogenesis. The present results suggest that upregulation of ACVR2B and its assembly could affect...

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Main Authors: Jimin Jeon, Hyemi Lee, Min‐Seung Jeon, Seok‐Jung Kim, Cham Choi, Ki Woo Kim, Dong Joo Yang, Sangho Lee, Yong‐Soo Bae, Won Il Choi, Juyeon Jung, Seong‐il Eyun, Siyoung Yang
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
ACVR2B assembly
arthritis treatment
druggable target
human OA cartilage
mouse model
Online Access:https://doi.org/10.1002/advs.202205161
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https://doi.org/10.1002/advs.202205161

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