The canine blood-brain barrier in health and disease: focus on brain protection
This review examines the role of the canine blood-brain barrier (BBB) in health and disease, focusing on the impact of the multidrug resistance (MDR) transporter P-glycoprotein (P-gp) encoded by the ABCB1/MDR1 gene. The BBB is critical in maintaining central nervous system homeostasis and brain prot...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Veterinary Quarterly |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/01652176.2025.2450041 |
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| author | Dimitri Bassalo Stephen G. Matthews Enrrico Bloise |
| author_facet | Dimitri Bassalo Stephen G. Matthews Enrrico Bloise |
| author_sort | Dimitri Bassalo |
| collection | DOAJ |
| description | This review examines the role of the canine blood-brain barrier (BBB) in health and disease, focusing on the impact of the multidrug resistance (MDR) transporter P-glycoprotein (P-gp) encoded by the ABCB1/MDR1 gene. The BBB is critical in maintaining central nervous system homeostasis and brain protection against xenobiotics and environmental drugs that may be circulating in the blood stream. We revise key anatomical, histological and functional aspects of the canine BBB and examine the role of the ABCB1/MDR1 gene mutation in specific dog breeds that exhibit reduced P-gp activity and disrupted drug brain pharmacokinetics. The review also covers factors that may disrupt the canine BBB, including the actions of aging, canine cognitive dysfunction, epilepsy, inflammation, infection, traumatic brain injury, among others. We highlight the critical importance of this barrier in maintaining central nervous system homeostasis and protecting against xenobiotics and conclude that a number of neurological-related diseases may increase vulnerability of the BBB in the canine species and discuss its profound impacts on canine health. |
| format | Article |
| id | doaj-art-27d2b170fb17453fa7e7bd6de3f64b44 |
| institution | Kabale University |
| issn | 0165-2176 1875-5941 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Veterinary Quarterly |
| spelling | doaj-art-27d2b170fb17453fa7e7bd6de3f64b442025-01-10T09:27:35ZengTaylor & Francis GroupVeterinary Quarterly0165-21761875-59412025-12-01451123210.1080/01652176.2025.2450041The canine blood-brain barrier in health and disease: focus on brain protectionDimitri Bassalo0Stephen G. Matthews1Enrrico Bloise2Especialização em Farmacologia, Departamento de Farmacologia, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilDepartment of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, CanadaDepartment of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, CanadaThis review examines the role of the canine blood-brain barrier (BBB) in health and disease, focusing on the impact of the multidrug resistance (MDR) transporter P-glycoprotein (P-gp) encoded by the ABCB1/MDR1 gene. The BBB is critical in maintaining central nervous system homeostasis and brain protection against xenobiotics and environmental drugs that may be circulating in the blood stream. We revise key anatomical, histological and functional aspects of the canine BBB and examine the role of the ABCB1/MDR1 gene mutation in specific dog breeds that exhibit reduced P-gp activity and disrupted drug brain pharmacokinetics. The review also covers factors that may disrupt the canine BBB, including the actions of aging, canine cognitive dysfunction, epilepsy, inflammation, infection, traumatic brain injury, among others. We highlight the critical importance of this barrier in maintaining central nervous system homeostasis and protecting against xenobiotics and conclude that a number of neurological-related diseases may increase vulnerability of the BBB in the canine species and discuss its profound impacts on canine health.https://www.tandfonline.com/doi/10.1080/01652176.2025.2450041P-glycoprotein (P-gp/ABCB1/MDR1)brain endothelial cells (BECs)infectionagingepilepsytraumatic brain injury (TBI) |
| spellingShingle | Dimitri Bassalo Stephen G. Matthews Enrrico Bloise The canine blood-brain barrier in health and disease: focus on brain protection Veterinary Quarterly P-glycoprotein (P-gp/ABCB1/MDR1) brain endothelial cells (BECs) infection aging epilepsy traumatic brain injury (TBI) |
| title | The canine blood-brain barrier in health and disease: focus on brain protection |
| title_full | The canine blood-brain barrier in health and disease: focus on brain protection |
| title_fullStr | The canine blood-brain barrier in health and disease: focus on brain protection |
| title_full_unstemmed | The canine blood-brain barrier in health and disease: focus on brain protection |
| title_short | The canine blood-brain barrier in health and disease: focus on brain protection |
| title_sort | canine blood brain barrier in health and disease focus on brain protection |
| topic | P-glycoprotein (P-gp/ABCB1/MDR1) brain endothelial cells (BECs) infection aging epilepsy traumatic brain injury (TBI) |
| url | https://www.tandfonline.com/doi/10.1080/01652176.2025.2450041 |
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