ECM remodeling by PDGFRβ+ dental pulp stem cells drives angiogenesis and pulp regeneration via integrin signaling

ECM remodeling by PDGFRβ+ dental pulp stem cells drives angiogenesis and pulp regeneration via integrin signaling

Abstract Background This study investigates the role of PDGFRβ+ dental pulp stem cells (DPSCs) in dental pulp vascular development by remodeling the extracellular matrix (ECM), with implications for angiogenesis and pulp regeneration using GelMA hydrogels. Methods PDGFRβ+ DPSCs were assessed for ECM...

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Bibliographic Details
Main Authors: Tiankai Di, Lulu Wang, Chao Feng, Jinlong Xu, Bo Shao, Baixiang Cheng, Liying Wang, Xiao Zhang, Ling Zhang, Yujiang Chen
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
Dental pulp regeneration
Dental pulp stem cells
Extracellular matrix
Angiogenesis
GelMA hydrogels
Online Access:https://doi.org/10.1186/s13287-025-04382-7
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https://doi.org/10.1186/s13287-025-04382-7

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