Whole-brain 3D imaging of dopaminergic neurons and glial cells in the mouse model of Parkinson’s disease induced by 6-OHDA

Whole-brain 3D imaging of dopaminergic neurons and glial cells in the mouse model of Parkinson’s disease induced by 6-OHDA

ObjectiveParkinson’s disease (PD) is the second most common neurodegenerative disease. Current understanding of the abnormal neural network in PD is limited, which may be one of the reasons for the lack of effective treatments. Tissue-clearing techniques allow visualization of neurons and gliocytes...

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Bibliographic Details
Main Authors: Mengqi Wang, Linglong Xiao, Yifeng Shi, Yaping Wu, Xinyuejia Huang, Yang Wu, Yangyang Xu, Lin Bai, Wei Pan, Jie Zhang, Wei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
3D pathology
whole-brain tissue-clearing
optical imaging
neural network
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1503168/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1503168/full

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