Tumor microenvironment-preserving gliosarcoma organoids as an in vitro preclinical platform: a comparative analysis with glioblastoma models

Tumor microenvironment-preserving gliosarcoma organoids as an in vitro preclinical platform: a comparative analysis with glioblastoma models

Abstract Background Gliosarcoma (GS) is a rare variant of glioblastoma (GBM), characterized by biphasic glial and sarcomatous histology and poor prognosis. Despite its distinct clinical features, GS remains underrepresented in glioma research due to the lack of biologically faithful and experimental...

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Bibliographic Details
Main Authors: Junseong Park, Dokyeong Kim, Hyeon-Chun Park, Minyoung Park, Songzi Zhang, Okcho Na, Youn Soo Lee, Minho Lee, Stephen Ahn, Yeun-Jun Chung
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Gliosarcoma
Patient-derived organoid
Precision oncology
Single-cell RNA sequencing
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12967-025-06952-y
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https://doi.org/10.1186/s12967-025-06952-y

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