Uncovering the Beneficial Role of <i>Limosilactobacillus fermentum</i> E7 Exhibiting Antioxidant Activity in Ameliorating DSS-Induced Ulcerative Colitis in a Murine Model
Background: Ulcerative colitis (UC) is a chronic intestinal disease of growing global concern. Bacteria associated with fermented food or probiotics regulate immune and inflammatory responses, playing a key role in intestinal immune homeostasis. Results: Five probiotics with relatively good antioxid...
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2025-01-01
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| author | Hongyan Zhang Hailing Wang Yue Li Yue Leng Ke Lin Dayong Ren |
| author_facet | Hongyan Zhang Hailing Wang Yue Li Yue Leng Ke Lin Dayong Ren |
| author_sort | Hongyan Zhang |
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| description | Background: Ulcerative colitis (UC) is a chronic intestinal disease of growing global concern. Bacteria associated with fermented food or probiotics regulate immune and inflammatory responses, playing a key role in intestinal immune homeostasis. Results: Five probiotics with relatively good antioxidant effects, namely <i>Lactiplantibacillus plantarum</i> H6, <i>Latilactobacillus sakei</i> QC9, <i>Limosilactobacillus fermentum</i> E7, <i>Bacillus subtills</i> D1, and <i>Bacillus licheniformis</i> Q13, were screened out from 30 strains of probiotics through in vitro antioxidant assays. The five probiotics had varying degrees of alleviating effects on UC mice and improved various physiological indicators, such as oxidative stress parameters and histopathological sections. The effects of E7, D1, and Q13 were more pronounced. Furthermore, E7 effectively regulated UC mouse intestinal microbiota composition, increased short-chain fatty acid concentration, and promoted the expression of anti-inflammatory factors, such as interleukin 10 (IL-10), while suppressing that of pro-inflammatory factors, such as interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α). Meanwhile, D1 and Q13 only exhibited partial alleviating effects. Finally, E7 increased the expression of tight junction proteins in colon tissues. Conclusions: E7 showed superior efficacy to other probiotics in alleviating UC, offering novel therapeutic prospects for safer and effective management of UC. |
| format | Article |
| id | doaj-art-279d009674f44442bac311eda3526d66 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-279d009674f44442bac311eda3526d662025-01-10T13:17:54ZengMDPI AGFoods2304-81582025-01-0114113710.3390/foods14010137Uncovering the Beneficial Role of <i>Limosilactobacillus fermentum</i> E7 Exhibiting Antioxidant Activity in Ameliorating DSS-Induced Ulcerative Colitis in a Murine ModelHongyan Zhang0Hailing Wang1Yue Li2Yue Leng3Ke Lin4Dayong Ren5College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaBackground: Ulcerative colitis (UC) is a chronic intestinal disease of growing global concern. Bacteria associated with fermented food or probiotics regulate immune and inflammatory responses, playing a key role in intestinal immune homeostasis. Results: Five probiotics with relatively good antioxidant effects, namely <i>Lactiplantibacillus plantarum</i> H6, <i>Latilactobacillus sakei</i> QC9, <i>Limosilactobacillus fermentum</i> E7, <i>Bacillus subtills</i> D1, and <i>Bacillus licheniformis</i> Q13, were screened out from 30 strains of probiotics through in vitro antioxidant assays. The five probiotics had varying degrees of alleviating effects on UC mice and improved various physiological indicators, such as oxidative stress parameters and histopathological sections. The effects of E7, D1, and Q13 were more pronounced. Furthermore, E7 effectively regulated UC mouse intestinal microbiota composition, increased short-chain fatty acid concentration, and promoted the expression of anti-inflammatory factors, such as interleukin 10 (IL-10), while suppressing that of pro-inflammatory factors, such as interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α). Meanwhile, D1 and Q13 only exhibited partial alleviating effects. Finally, E7 increased the expression of tight junction proteins in colon tissues. Conclusions: E7 showed superior efficacy to other probiotics in alleviating UC, offering novel therapeutic prospects for safer and effective management of UC.https://www.mdpi.com/2304-8158/14/1/137hyperuricemia<i>Limosilactobacillus fermentum</i> E7antioxidant activityulcerative colitisintestinal barrier functiongut microbiota |
| spellingShingle | Hongyan Zhang Hailing Wang Yue Li Yue Leng Ke Lin Dayong Ren Uncovering the Beneficial Role of <i>Limosilactobacillus fermentum</i> E7 Exhibiting Antioxidant Activity in Ameliorating DSS-Induced Ulcerative Colitis in a Murine Model Foods hyperuricemia <i>Limosilactobacillus fermentum</i> E7 antioxidant activity ulcerative colitis intestinal barrier function gut microbiota |
| title | Uncovering the Beneficial Role of <i>Limosilactobacillus fermentum</i> E7 Exhibiting Antioxidant Activity in Ameliorating DSS-Induced Ulcerative Colitis in a Murine Model |
| title_full | Uncovering the Beneficial Role of <i>Limosilactobacillus fermentum</i> E7 Exhibiting Antioxidant Activity in Ameliorating DSS-Induced Ulcerative Colitis in a Murine Model |
| title_fullStr | Uncovering the Beneficial Role of <i>Limosilactobacillus fermentum</i> E7 Exhibiting Antioxidant Activity in Ameliorating DSS-Induced Ulcerative Colitis in a Murine Model |
| title_full_unstemmed | Uncovering the Beneficial Role of <i>Limosilactobacillus fermentum</i> E7 Exhibiting Antioxidant Activity in Ameliorating DSS-Induced Ulcerative Colitis in a Murine Model |
| title_short | Uncovering the Beneficial Role of <i>Limosilactobacillus fermentum</i> E7 Exhibiting Antioxidant Activity in Ameliorating DSS-Induced Ulcerative Colitis in a Murine Model |
| title_sort | uncovering the beneficial role of i limosilactobacillus fermentum i e7 exhibiting antioxidant activity in ameliorating dss induced ulcerative colitis in a murine model |
| topic | hyperuricemia <i>Limosilactobacillus fermentum</i> E7 antioxidant activity ulcerative colitis intestinal barrier function gut microbiota |
| url | https://www.mdpi.com/2304-8158/14/1/137 |
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