Lamin A/C promotes HBV transcription by modulating histone modification associated with cccDNA minichromosome in an HBx-dependent manner

Lamin A/C promotes HBV transcription by modulating histone modification associated with cccDNA minichromosome in an HBx-dependent manner

Abstract Background Chronic hepatitis B virus (HBV) infection remains a serious public health challenge, and primary treatment strategies are unable to cure HBV infection due to the persistence of HBV covalently closed circular DNA (cccDNA) in the nuclei of cells. The HBV X protein (HBx) plays a cru...

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Bibliographic Details
Main Authors: Linshan Jiang, Lanlang Peng, Hong Chen, Fangli Liao, Liping Yang, Yuanyuan Ye, Gaoli Zhang, Hua Sun, Qin Hu, Weixian Chen
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Virology Journal
Subjects:
HBV
cccDNA
HBx
Lamin A/C
Online Access:https://doi.org/10.1186/s12985-025-02820-9
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https://doi.org/10.1186/s12985-025-02820-9

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