stGRL: spatial domain identification, denoising, and imputation algorithm for spatial transcriptome data based on multi-task graph contrastive representation learning

Abstract Background Spatial transcriptomics now enables sequencing while preserving the spatial location of cells. This significantly enhances researchers' understanding of cellular and tissue functions in their spatial context. However, due to current technical limitations, spatial transcripto...

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Bibliographic Details
Main Authors: Xin Lu, Murong Zhou, Bo Gao, Fang Wang, Shuilin Jin, Qiaoming Liu, Guohua Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Biology
Subjects:
Online Access:https://doi.org/10.1186/s12915-025-02290-z
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