Direct and indirect RANK and CD40 signaling regulate the maintenance of thymic epithelial cell frequency and properties in the adult thymus

Direct and indirect RANK and CD40 signaling regulate the maintenance of thymic epithelial cell frequency and properties in the adult thymus

Medullary thymic epithelial cells (mTECs) play a crucial role in suppressing the onset of autoimmunity by eliminating autoreactive T cells and promoting the development of regulatory T cells in the thymus. Although mTECs undergo turnover in adults, the molecular mechanisms behind this process remain...

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Bibliographic Details
Main Authors: Mio Hayama, Hiroto Ishii, Maki Miyauchi, Masaki Yoshida, Naho Hagiwara, Wataru Muramtatu, Kano Namiki, Rin Endo, Takahisa Miyao, Nobuko Akiyama, Taishin Akiyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
thymic epithelial cell (TEC)
self-tolerance
TNF receptor (TNFR) family
progenitor
AIRE
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500908/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500908/full

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