Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia

Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia

Exposure to air pollution is associated with neurological diseases. Traffic is a major source of air pollution, consisting of a complex mixture of ultrafine particles, that can invade the brain and induce a microglia-mediated inflammatory response. However, the exact mechanisms of how traffic-relate...

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Main Authors: Sohvi Ohtonen, Henna Jäntti, Luca Giudice, Ahmed Mohamed, Anastasia Shakirzyanova, Táňa Závodná, Ilya Belevich, Hong Yan, Angélica María Sabogal-Guáqueta, Liudmila Saveleva, Mari-Anna Väänänen, Ashley Rillo-Albert, Elisa Perciballi, Daniela Ferrari, Minna-Mari Tervo, Mireia Gómez-Budia, Zdeněk Krejčík, Päivi Aakko-Saksa, Jari Koistinaho, Šárka Lehtonen, Katja M. Kanninen, Jan Topinka, Eija Jokitalo, Alejandra Sierra, Martina Schmidt, Amalia M. Dolga, Pasi I. Jalava, Paula Korhonen, Tarja Malm
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Environment International
Subjects:
Human microglia
iPSC
Air pollution
Lysosome
Diesel
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412025002181
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