Mutational Landscape Assessed in Tumor Tissue and Circulating Tumor DNA During Treatment of Patients with HER2/ERBB2-Mutated Solid Tumors

Mutational Landscape Assessed in Tumor Tissue and Circulating Tumor DNA During Treatment of Patients with HER2/ERBB2-Mutated Solid Tumors

Abstract Background Human epidermal growth factor receptor 2 (HER2) aberrations, such as protein overexpression and amplification of the HER2 gene (ERBB2), are well-established in breast and gastroesophageal adenocarcinomas. However, ERBB2 oncogenic variants occur in 3.5% of all solid tumors with po...

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Main Authors: Kristian Egebjerg, Iben Spanggaard, Lise Barlebo Ahlborn, Kristoffer Staal Rohrberg, Laurine Harsloef, Martin Hoejgaard, Ane Yde Schmidt, Ulrik Lassen, Ida Viller Tuxen, Jane Preuss Hasselby, Maria Rossing, Eric Santoni-Rugiu, Christina Westmose Yde, Morten Mau-Sørensen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
HER2
ERBB2
Mutations
ctDNA
Cancer
Online Access:https://doi.org/10.1186/s12885-025-14599-7
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https://doi.org/10.1186/s12885-025-14599-7

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