Population pharmacokinetics and pharmacogenomics of edoxaban in Japanese adults with atrial fibrillation

Population pharmacokinetics and pharmacogenomics of edoxaban in Japanese adults with atrial fibrillation

Abstract Background Edoxaban is used as an anti-coagulant to prevent cardioembolic infarction, deep vein thrombosis, and pulmonary embolism. Edoxaban pharmacokinetics have been reported to be affected by several factors such as renal function, age, body weight, and the concomitant use of P-glycoprot...

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Main Authors: Satoshi Ueshima, Daiki Hira, Sayana Matsuda, Rio Michihata, Yohei Tabuchi, Tomoya Ozawa, Hideki Itoh, Moritake Iguchi, Masaharu Akao, Takanori Aizawa, Asami Kashiwa, Satoshi Shizuta, Takeru Makiyama, Yoshihisa Nakagawa, Minoru Horie, Tomohiro Terada, Toshiya Katsura
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Edoxaban
Pharmacokinetics
Pharmacogenomics
Non-linear mixed-effects modeling
Atrial fibrillation
Online Access:https://doi.org/10.1186/s40780-025-00453-2
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https://doi.org/10.1186/s40780-025-00453-2

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