The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity

The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity

Abstract Obesity is associated with the gut microbiome. Here, we report that gut commensal Clostridia bacteria regulate host energy balance through the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA). IPA acts as an endogenous leptin sensitiser to counteract obesity. Mechanistically, IPA...

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Bibliographic Details
Main Authors: Zhiwei Wang, Shaying Yang, Liangju Liu, Aiqin Mao, Hao Kan, Fan Yu, Xin Ma, Lei Feng, Tingting Zhou
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Clinical and Translational Medicine
Subjects:
gut microbiome
IPA
leptin sensitivity
metabolism
obesity
STAT3
Online Access:https://doi.org/10.1002/ctm2.70053
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