sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models

sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models

Abstract Background Haploinsufficiency of the progranulin (PGRN) protein is a leading cause of frontotemporal lobar degeneration (FTLD). Mouse models have been developed to study PGRN functions. However, PGRN deficiency in the commonly used C57BL/6 mouse strain background leads to very mild phenotyp...

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Main Authors: Cha Yang, Huan Du, Gwang Bin Lee, Masaaki Uematsu, Weiguo He, Etienne Doré, Weizhi Yu, Ethan J. Sanford, Marcus B. Smolka, Eric Boilard, Jeremy M. Baskin, Ling Hao, Fenghua Hu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Neurodegeneration
Subjects:
Progranulin
Inflammation
Lysosome
Mouse strain background
sPLA2-IIA
Mitochondria
Online Access:https://doi.org/10.1186/s13024-025-00863-8
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https://doi.org/10.1186/s13024-025-00863-8

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