Development and validation of optimized lentivirus-like particles for gene editing tool delivery with Gag-Only strategy

Development and validation of optimized lentivirus-like particles for gene editing tool delivery with Gag-Only strategy

Abstract Background The development of gene editing tools such as CRISPR-Cas9 and base editors (BE) is critical for genetic diseases and cancer. Lentivirus-like particles (LVLPs) grows into an auspicious platform for delivering mRNA or ribonucleic proteins (RNPs) due to it integrates the advantage o...

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Bibliographic Details
Main Authors: Jinlin Jia, Yanzhe Hao, Lu Zhang, Xiaofang Cao, Lisha An, Hu Wang, Qi Ma, Xiaohua Jin, Xu Ma
Format: Article
Language:English
Published: BMC 2025-04-01
Series:European Journal of Medical Research
Subjects:
Lentivirus-like particles (LVLPs)
MRNA
Base editing
Packaging signal
Gag-only
Online Access:https://doi.org/10.1186/s40001-025-02499-2
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https://doi.org/10.1186/s40001-025-02499-2

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