α-Synuclein orchestrates Th17 responses as antigen and adjuvant in Parkinson’s disease

α-Synuclein orchestrates Th17 responses as antigen and adjuvant in Parkinson’s disease

Abstract Recently, the role of T cells in the pathology of α-synuclein (αS)-mediated neurodegenerative disorders called synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy, has attracted increasing attention. Although the existence of α...

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Main Authors: Emi Furusawa-Nishii, Bataa Solongo, Kou Rai, Soichiro Yoshikawa, Asako Chiba, Ayami Okuzumi, Shin-ichi Ueno, Yasunobu Hoshino, Yoko Imamichi-Tatano, Haruka Kimura, Taku Hatano, Nobutaka Hattori, Sachiko Miyake
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Neuroinflammation
Subjects:
synucleinopathy
α-synuclein specific T cells
TLR 4
spliced X-box binding protein
IL-23
Online Access:https://doi.org/10.1186/s12974-025-03359-w
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https://doi.org/10.1186/s12974-025-03359-w

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