Transcriptional Regulation of De Novo Lipogenesis by SIX1 in Liver Cancer Cells

Transcriptional Regulation of De Novo Lipogenesis by SIX1 in Liver Cancer Cells

Abstract De novo lipogenesis (DNL), a hallmark of cancer, facilitates tumor growth and metastasis. Therapeutic drugs targeting DNL are being developed. However, how DNL is directly regulated in cancer remains largely unknown. Here, transcription factor sine oculis homeobox 1 (SIX1) is shown to direc...

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Bibliographic Details
Main Authors: Ling Li, Xiujuan Zhang, Guang Xu, Rui Xue, Shuo Li, Shumeng Wu, Yuanjun Yang, Yanni Lin, Jing Lin, Guoxiao Liu, Shan Gao, Youzhi Zhang, Qinong Ye
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
de novo lipogenesis
noncoding RNA
SIX1
transcription factor
tumor growth and metastasis
Online Access:https://doi.org/10.1002/advs.202404229
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https://doi.org/10.1002/advs.202404229

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