Pharmacological modulation of inflammatory oligodendrocyte progenitor cells using three multiple sclerosis disease modifying therapies in vitro

Pharmacological modulation of inflammatory oligodendrocyte progenitor cells using three multiple sclerosis disease modifying therapies in vitro

Preclinical studies of pro-remyelinating therapies for multiple sclerosis tend to neglect the effect of the disease-relevant inflammatory milieu. Interferon-gamma (IFN-γ) is known to suppress oligodendrocyte progenitor cell (OPC) differentiation and induce a recently described immune OPC (iOPC) phen...

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Bibliographic Details
Main Authors: Larissa Jank, Riley B. Catenacci, Veronica Minney, Danny Galleguillos, Peter A. Calabresi
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Neurotherapeutics
Subjects:
Remyelination
OPC
Cladribine
Dimethylfumarate
IFN-β
Multiple sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1878747924000655
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