Mesocorticolimbic dopaminergic innervation modulates Levodopa-related improvements in gait in older slow walking Adults: A [11C]PE2I PET study

Mesocorticolimbic dopaminergic innervation modulates Levodopa-related improvements in gait in older slow walking Adults: A [11C]PE2I PET study

Purpose: Slow walking in healthy older adults may result from multifactorial deficits involving the muscular, peripheral, and central nervous systems. While mobility depends on these systems, the brain’s neuromodulatory capacity may offer insights for interventions. This open-label imaging study tes...

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Bibliographic Details
Main Authors: N. Paalanen, S. Roytman, M. van Emde Boas, A. Biddix, A. Luker, F. Michalakis, G. Carli, P. Kanel, C. Pongmala, R. Koeppe, L.M. Chahine, C. Rosano, N.I. Bohnen
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Clinical Parkinsonism & Related Disorders
Subjects:
[11C]PE2I
PET/CT
Gait
Mobility
Dopaminergic resilience
Online Access:http://www.sciencedirect.com/science/article/pii/S259011252500057X
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