CB2 and TRPV1 receptors in inflammatory state of macrophages from sickle cell anemia pediatric/young adults

CB2 and TRPV1 receptors in inflammatory state of macrophages from sickle cell anemia pediatric/young adults

Abstract Sickle Cell Disease (SCD) is a monogenic disorder characterized by the production of abnormal hemoglobin. Polymerization of HbS causes sickling of red blood cells (RBCs) evidenced by acute adverse events and persistent inflammatory state, vasculopathy and organ damage. Sickled RBCs cause an...

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Main Authors: Giuseppe Di Feo, Giulia Giliberti, Deeksha Rana-Seyfert, Maria Maddalena Marrapodi, Maddalena Casale, Shakeel Ahmed, Silverio Perrotta, Francesca Rossi, Domenico Roberti, Alessandra Di Paola
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Sickle cell anemia
Inflammation
Macrophage polarization
Iron metabolism
Endocannabinoid/Endovanilloid system
Online Access:https://doi.org/10.1038/s41598-025-15028-2
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https://doi.org/10.1038/s41598-025-15028-2

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