Cardiopulmonary Exercise Testing: Deciphering Cardiovascular Complications in Systemic Sclerosis
Cardiac manifestations in systemic sclerosis (SSc) are variable and are associated with a poor prognosis, frequently resulting in impaired right ventricular function and heart failure. A high proportion of patients with SSc experience pulmonary arterial hypertension (PAH), interstitial lung disease,...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-01-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25914 |
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| author | Ailia Giubertoni Mattia Bellan Luca Cumitini Giuseppe Patti |
| author_facet | Ailia Giubertoni Mattia Bellan Luca Cumitini Giuseppe Patti |
| author_sort | Ailia Giubertoni |
| collection | DOAJ |
| description | Cardiac manifestations in systemic sclerosis (SSc) are variable and are associated with a poor prognosis, frequently resulting in impaired right ventricular function and heart failure. A high proportion of patients with SSc experience pulmonary arterial hypertension (PAH), interstitial lung disease, or myocardial involvement, all of which can lead to exercise intolerance. In this context, cardiopulmonary exercise testing (CPET) is a useful tool for diagnosing exercise intolerance, elucidating its pathophysiology, and assessing its prognosis. CPET can also identify patients with SSc at higher risk of developing PAH. Despite its utility, current guidelines for CPET do not include the evaluation of patients with SSc, nor do standard SSc management guidelines consider CPET in the clinical work-up. This review summarizes the development, supporting evidence, and application of CPET in assessing cardiac involvement in patients with SSc. |
| format | Article |
| id | doaj-art-26e9bbab18b647c0b6b3d3d38f686241 |
| institution | Kabale University |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-26e9bbab18b647c0b6b3d3d38f6862412025-01-25T10:41:20ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-01-012612591410.31083/RCM25914S1530-6550(24)01632-6Cardiopulmonary Exercise Testing: Deciphering Cardiovascular Complications in Systemic SclerosisAilia Giubertoni0Mattia Bellan1Luca Cumitini2Giuseppe Patti3Division of Cardiology, Maggiore della Carità Hospital, 28100 Novara, ItalyDepartment of Translational Medicine, University of Eastern Piedmont, 28100 Novara, ItalyDivision of Cardiology, Maggiore della Carità Hospital, 28100 Novara, ItalyDivision of Cardiology, Maggiore della Carità Hospital, 28100 Novara, ItalyCardiac manifestations in systemic sclerosis (SSc) are variable and are associated with a poor prognosis, frequently resulting in impaired right ventricular function and heart failure. A high proportion of patients with SSc experience pulmonary arterial hypertension (PAH), interstitial lung disease, or myocardial involvement, all of which can lead to exercise intolerance. In this context, cardiopulmonary exercise testing (CPET) is a useful tool for diagnosing exercise intolerance, elucidating its pathophysiology, and assessing its prognosis. CPET can also identify patients with SSc at higher risk of developing PAH. Despite its utility, current guidelines for CPET do not include the evaluation of patients with SSc, nor do standard SSc management guidelines consider CPET in the clinical work-up. This review summarizes the development, supporting evidence, and application of CPET in assessing cardiac involvement in patients with SSc.https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25914cardiopulmonary exercise testingpulmonary arterial hypertensionheart failuresystemic sclerosis |
| spellingShingle | Ailia Giubertoni Mattia Bellan Luca Cumitini Giuseppe Patti Cardiopulmonary Exercise Testing: Deciphering Cardiovascular Complications in Systemic Sclerosis Reviews in Cardiovascular Medicine cardiopulmonary exercise testing pulmonary arterial hypertension heart failure systemic sclerosis |
| title | Cardiopulmonary Exercise Testing: Deciphering Cardiovascular Complications in Systemic Sclerosis |
| title_full | Cardiopulmonary Exercise Testing: Deciphering Cardiovascular Complications in Systemic Sclerosis |
| title_fullStr | Cardiopulmonary Exercise Testing: Deciphering Cardiovascular Complications in Systemic Sclerosis |
| title_full_unstemmed | Cardiopulmonary Exercise Testing: Deciphering Cardiovascular Complications in Systemic Sclerosis |
| title_short | Cardiopulmonary Exercise Testing: Deciphering Cardiovascular Complications in Systemic Sclerosis |
| title_sort | cardiopulmonary exercise testing deciphering cardiovascular complications in systemic sclerosis |
| topic | cardiopulmonary exercise testing pulmonary arterial hypertension heart failure systemic sclerosis |
| url | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25914 |
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