High mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity

High mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity

Abstract Esophageal squamous cell carcinoma (ESCC) is a common and aggressive cancer with limited responses to immunotherapy. High mobility group A1 (HMGA1), a chromatin remodeling protein, plays a key role in tumor progression, but its impact on anti-tumor immunity in ESCC remains unclear. Here we...

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Main Authors: Kai-Yue He, Annie Zhao, Jin-Rong Guo, Dan-Hui Wu, Huai Liu, Fan Gao, Meng-Jie Liu, Jing-Yu Yang, Xin-Yuan Lei, Jun-Qi Li, Lei Zhang, Zhen-Hua Yan, Qiang Ding, Yong-Wei Huang, Rutao Cui, Yong-Ping Jian, Zhi-Xiang Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60221-6
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https://doi.org/10.1038/s41467-025-60221-6

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