Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway

Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway

BackgroundHypoxia-induced pulmonary vascular remodeling is central to the development of high-altitude pulmonary hypertension (HAPH). Rhodiola tangutica has traditionally been used to prevent chronic mountain sickness. Although its active fraction (ACRT) shows therapeutic potential for HAPH, the mai...

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Bibliographic Details
Main Authors: Na Yang, Meiduo Huayu, Shanshan Su, Bin Hou, Zhanting Yang, Xingmei Nan, Zhanqiang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
Rhodiola tangutica
bioactive equivalent combinatorial components
high-altitude pulmonary hypertension
pulmonary artery vascular remodeling
antioxidant
antiproliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1582677/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1582677/full

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