Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9

Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9

Abstract CRISPR-Cas9 is now the leading method for genome editing and is advancing for the treatment of human disease. CRIPSR has promise in treating neurological diseases, but traditional viral-vector-delivery approaches have neurotoxicity limiting their use. Here we describe a simple method for no...

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Main Authors: Seph M. Palomino, Katherin A. Gabriel, Juliet M. Mwirigi, Anna Cervantes, Peter Horton, Geoffrey Funk, Aubin Moutal, Laurent F. Martin, Rajesh Khanna, Theodore J. Price, Amol Patwardhan
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-91153-2
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https://doi.org/10.1038/s41598-025-91153-2

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