Uric acid reduces the expression of aquaporins in renal collecting ducts to increase urine output in hyperuricemia

Uric acid reduces the expression of aquaporins in renal collecting ducts to increase urine output in hyperuricemia

BackgroundHyperuricemia (HUA) has attracted wide attention due to its close relationship with gout, hypertension, hypertriglyceridemia, obesity, atherosclerotic heart disease, type 2 diabetes and chronic kidney disease. Clinical observations suggest that people with high levels of serum uric acid (s...

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Bibliographic Details
Main Authors: Xiaohui Cui, Rongfang Qiao, Bing Wang, Yitong Hu, Guoying Sun, Wenjuan Hu, Zhilin Luan, Huiwen Ren, Hu Xu, Youfei Guan, Xiaoyan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Physiology
Subjects:
hyperuricemia
uric acid
aquaporin
NF-κB
collecting ducts
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1504328/full
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https://www.frontiersin.org/articles/10.3389/fphys.2025.1504328/full

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