Mitochondrial Amount Determines Doxorubicin‐Induced Cardiotoxicity in Cardiomyocytes

Mitochondrial Amount Determines Doxorubicin‐Induced Cardiotoxicity in Cardiomyocytes

Abstract Doxorubicin, an anthracycline commonly used for treating cancer patients, is known for its cardiotoxic side‐effects. Although dose‐dependent, but susceptibility remains variable among patients, and childhood‐exposure‐adult‐onset remains challenging. Besides topoisomerase toxicity, Doxorubic...

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Bibliographic Details
Main Authors: Weiyao Xiong, Bin Li, Jianan Pan, Dongjiu Li, Haihua Yuan, Xin Wan, Yanjie Zhang, Lijun Fu, Junfeng Zhang, Ming Lei, Alex Chia Yu Chang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
cGAS‐STING
doxorubicin induced cardiotoxicity
mitochondrial amount
mitochondrial transplantation
senescence
Online Access:https://doi.org/10.1002/advs.202412017
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https://doi.org/10.1002/advs.202412017

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