Leveraged Vaccination to Alleviate Original Antigenic Sin for Enhancing Broad‐Neutralizing Antibody Response against SARS‐CoV‐2 Omicron Subvariants

Leveraged Vaccination to Alleviate Original Antigenic Sin for Enhancing Broad‐Neutralizing Antibody Response against SARS‐CoV‐2 Omicron Subvariants

ABSTRACT Original antigenic sin (OAS), or immune imprinting, triggered by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) ancestral (WT) strain vaccine, or infection, has led to weakened neutralizing antibody response against Omicron variant like BA.2 and subvariant like XBB. This calls...

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Main Authors: Guangxu Zhang, Qian Wang, Kai Ji, Yuanzhou Wang, Wei Xu, Jie Zhou, Zezhong Liu, Ruixue Xiu, Lixiao Xing, Jianghao Zhou, Yuren Shi, Xishan Lu, Xuanyi Wang, Bo Ying, Lu Lu, Shibo Jiang
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:MedComm
Subjects:
original antigenic sin (OAS)
Omicron subvariants
mRNA vaccine
broad‐neutralizing antibody (bnAb)
Online Access:https://doi.org/10.1002/mco2.70273
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https://doi.org/10.1002/mco2.70273

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